Mitotic spindle assembly

Across TCGA patient cohorts, RNA activity of the Mitotic spindle assembly pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SGO1, FANCB, and FOXM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic spindle assembly activity versus SGO1 in UCEC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SGO1 →	+1.388	+0.264	<.001	<.001	3	6
UCEC	FANCB →	+0.928	+0.229	<.001	<.001	3	6
LUAD	FOXM1 →	+1.293	+0.237	<.001	<.001	3	6
LUAD	EXO1 →	+1.199	+0.211	<.001	<.001	3	6
LUAD	FBXO5 →	+0.662	+0.183	.001	.003	3	6
LUAD	KIF23 →	+1.266	+0.240	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090307 vs SGO1 — UCEC

Explore this scatter interactively →