Mitotic spindle assembly

Across TCGA cell cohorts, RNA activity of the Mitotic spindle assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNTA1, RPS27L, and LIMS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic spindle assembly activity versus SNTA1 in BLOOD_Leukemia (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SNTA1 →	+1.397	+0.240	<.001	<.001	3	6
SOFT_TISSUE	RPS27L →	-1.230	-0.278	.002	.004	3	6
BLOOD_Leukemia	LIMS2 →	+2.483	+0.208	<.001	<.001	3	5
BREAST	CAMK2N1 →	-2.377	-0.192	.001	.003	3	5
BREAST	GJC1 →	+2.056	+0.168	.003	.001	3	5
BLOOD_Leukemia	TTF1 →	+1.121	+0.224	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090307 vs SNTA1 — BLOOD_Leukemia

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