Meiotic spindle assembly

Across TCGA patient cohorts, RNA activity of the Meiotic spindle assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1_T506, RPL12_S38, and RRM1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic spindle assembly activity versus RFC1_T506 in LUAD (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RFC1_T506 →	+1.269	+0.148	<.001	<.001	3	10
LUAD	RPL12_S38 →	+1.231	+0.144	<.001	<.001	3	10
OV	RRM1 →	+0.416	+0.092	<.001	<.001	3	10
LUAD	RRM2 →	+0.975	+0.141	<.001	<.001	3	10
UCEC	RRP36_S73 →	+0.881	+0.157	<.001	<.001	3	10
LUAD	RSF1_S397 →	+1.055	+0.127	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090306 vs RFC1_T506 — LUAD

Explore this scatter interactively →