Meiotic spindle assembly

Across TCGA cell cohorts, RNA activity of the Meiotic spindle assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMURF1, KCNJ1, and PPRC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMURF1 grouped by Meiotic spindle assembly-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SMURF1 →	-0.232	-0.121	.001	<.001	3	4
LUNG_NSCLC_LUAD	KCNJ1 →	-0.093	-0.072	.002	.002	3	4
BONE	PPRC1 →	+0.366	+0.125	.004	.005	3	4
OVARY	MAP4K3 →	+0.164	+0.145	.007	<.001	3	4
URINARY_TRACT	LRRC55 →	+0.169	+0.111	.006	<.001	3	3
URINARY_TRACT	ATP6V0C →	+0.886	+0.111	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMURF1 by Meiotic spindle assembly activity — BLOOD_Myeloma

Explore this box plot interactively →