Meiotic spindle assembly

Across TCGA cell cohorts, RNA activity of the Meiotic spindle assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTC36, ARRB2, and COL17A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic spindle assembly activity versus TTC36 in LUNG_NSCLC_LUAD (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TTC36 →	+0.401	+0.149	.004	.002	3	5
URINARY_TRACT	ARRB2 →	-1.596	-0.353	.005	.005	3	5
URINARY_TRACT	COL17A1 →	+6.622	+0.471	<.001	.002	3	5
URINARY_TRACT	CBFB →	-0.661	-0.304	.004	.004	3	5
BREAST	PLA2G4F →	+1.274	+0.171	.004	.004	3	5
BREAST	P2RX5 →	-1.537	-0.226	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090306 vs TTC36 — LUNG_NSCLC_LUAD

Explore this scatter interactively →