Positive regulation of wound healing

Across TCGA patient cohorts, RNA activity of the Positive regulation of wound healing pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FN1, THBS1, and ITGA11, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of wound healing activity versus FN1 in THYM (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	FN1 →	+2.926	+0.043	<.001	<.001	3	32
THYM	THBS1 →	+1.994	+0.061	<.001	<.001	3	32
OV	ITGA11 →	+1.872	+0.054	<.001	<.001	3	32
SCLC	FILIP1L →	+1.792	+0.112	<.001	<.001	3	32
BLCA	C1S →	+1.901	+0.041	<.001	<.001	3	32
THYM	PDGFRB →	+1.594	+0.056	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090303 vs FN1 — THYM

Explore this scatter interactively →