Positive regulation of wound healing

Across TCGA cell cohorts, RNA activity of the Positive regulation of wound healing pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF157, VPS13D, and ACRBP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNF157 grouped by Positive regulation of wound healing-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RNF157 →	+2.195	+0.382	.001	.002	3	4
OVARY	VPS13D →	-0.753	-0.754	.001	.007	3	3
SKIN	ACRBP →	+0.251	+0.514	.007	.006	3	3
LIVER	MTHFD2 →	-4.440	-0.397	.001	.001	3	3
OESOPHAGUS	UQCRHL →	-0.712	-0.236	.005	<.001	3	3
OESOPHAGUS	DAPK2 →	-1.278	-0.268	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNF157 by Positive regulation of wound healing activity — LIVER

Explore this box plot interactively →