Negative regulation of cellular response to growth factor stimulus

Across TCGA cell cohorts, RNA activity of the Negative regulation of cellular response to growth factor stimulus pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BLZF1, BACE2, and TPSG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BLZF1 grouped by Negative regulation of cellular response to growth factor stimulus-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	BLZF1 →	-0.123	-0.287	.003	.003	3	5
SOFT_TISSUE	BACE2 →	-0.476	-0.370	.004	<.001	3	5
BLOOD_Myeloma	TPSG1 →	-0.624	-0.267	.001	.004	3	5
URINARY_TRACT	DAZAP1 →	-0.221	-0.241	.002	.002	3	4
UPPER_AERODIGESTIVE_TRACT	MRPS25 →	-0.185	-0.322	.007	.004	3	4
UPPER_AERODIGESTIVE_TRACT	PTHLH →	-0.238	-0.308	.006	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BLZF1 by Negative regulation of cellular response to growth factor stimulus activity — URINARY_TRACT

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