Negative regulation of cellular response to growth factor stimulus

Across TCGA cell cohorts, RNA activity of the Negative regulation of cellular response to growth factor stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMAD7, NDRG1, and SCP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMAD7 grouped by Negative regulation of cellular response to growth factor stimulus-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SMAD7 →	-1.735	-1.053	.001	.002	3	3
BLOOD_Leukemia	NDRG1 →	-2.418	-0.936	.008	.002	3	3
SKIN	SCP2 →	-0.444	-0.512	<.001	.004	3	3
SOFT_TISSUE	SLC9A3R1 →	-1.319	-0.264	.001	<.001	3	3
URINARY_TRACT	NSMCE2 →	-0.464	-0.245	<.001	.001	2	4
UPPER_AERODIGESTIVE_TRACT	MYBL2 →	-2.198	-0.255	.006	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMAD7 by Negative regulation of cellular response to growth factor stimulus activity — BLOOD_Leukemia

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