Negative regulation of cellular response to growth factor stimulus

Across TCGA cell cohorts, RNA activity of the Negative regulation of cellular response to growth factor stimulus pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP10A, PHKA1, and FOXD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP10A grouped by Negative regulation of cellular response to growth factor stimulus-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ATP10A →	-0.304	-0.093	.006	.001	3	5
SOFT_TISSUE	PHKA1 →	+0.176	+0.061	.002	<.001	3	4
KIDNEY	FOXD1 →	-0.129	-0.046	.001	.007	3	4
LARGE_INTESTINE	ACLY →	-0.369	-0.099	.003	<.001	3	4
LARGE_INTESTINE	ISY1-RAB43 →	-0.174	-0.075	.009	.002	3	4
LUNG_SCLC	KLHL4 →	-0.293	-0.086	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP10A by Negative regulation of cellular response to growth factor stimulus activity — BONE

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