Negative regulation of cellular response to growth factor stimulus

Across TCGA cell cohorts, RNA activity of the Negative regulation of cellular response to growth factor stimulus pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM144, ACO2, and IFI44, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cellular response to growth factor stimulus activity versus TMEM144 in OVARY (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TMEM144 →	-0.817	-1.420	.005	<.001	3	6
STOMACH	ACO2 →	-0.902	-1.469	.008	.001	3	6
SOFT_TISSUE	IFI44 →	+3.682	+1.518	.005	.001	3	5
LIVER	MSI2 →	-1.961	-1.756	.006	.001	3	5
LUNG_SCLC	IFT52 →	+0.597	+0.833	.005	.002	3	5
LIVER	CPT2 →	-0.792	-2.038	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090288 vs TMEM144 — OVARY

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