Regulation of mitotic cell cycle spindle assembly checkpoint

Across TCGA cell cohorts, RNA activity of the Regulation of mitotic cell cycle spindle assembly checkpoint pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTO1, UBR3, and PDE6D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTO1 grouped by Regulation of mitotic cell cycle spindle assembly checkpoint-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MTO1 →	-0.770	-0.184	.006	<.001	3	4
BLOOD_Myeloma	UBR3 →	-0.653	-0.163	.004	.003	3	4
KIDNEY	PDE6D →	-0.679	-0.279	.001	.006	2	5
LUNG_NSCLC_LUSC	OSGEPL1 →	-1.497	-0.207	.001	.008	3	4
PANCREAS	ZCWPW2 →	-0.284	-0.235	.001	<.001	3	4
PANCREAS	PRIMPOL →	-0.855	-0.209	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTO1 by Regulation of mitotic cell cycle spindle assembly checkpoint activity — BLOOD_Myeloma

Explore this box plot interactively →