Regulation of mitotic cell cycle spindle assembly checkpoint

Across TCGA cell cohorts, RNA activity of the Regulation of mitotic cell cycle spindle assembly checkpoint pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRR3, KCNK6, and CAVIN4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitotic cell cycle spindle assembly checkpoint activity versus PRR3 in STOMACH (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PRR3 →	+0.975	+0.928	.001	.003	3	6
BLOOD_Leukemia	KCNK6 →	-1.730	-0.807	.001	.002	3	5
PANCREAS	CAVIN4 →	+0.552	+1.110	.004	.002	3	5
URINARY_TRACT	FSD1 →	+2.642	+1.578	.008	<.001	3	5
URINARY_TRACT	ASXL1 →	+0.980	+1.250	.007	.005	3	5
BLOOD_Leukemia	NRF1 →	+0.601	+0.780	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090266 vs PRR3 — STOMACH

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