Positive regulation of canonical Wnt signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of canonical Wnt signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXOC6, RNU5F-4P, and MZF1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of canonical Wnt signaling pathway activity versus EXOC6 in HNSC (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EXOC6 →	-0.564	-0.387	.003	.004	3	3
HNSC	RNU5F-4P →	-0.680	-0.445	.001	.008	3	3
OV	MZF1 →	+0.842	+0.254	.001	.008	3	3
LUAD	RBMS2 →	+0.537	+0.142	<.001	<.001	3	3
COAD	SRPX →	+0.617	+0.505	<.001	.001	3	3
COAD	RUNX1 →	+0.856	+0.769	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090263 vs EXOC6 — HNSC

Explore this scatter interactively →