Positive regulation of canonical Wnt signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of canonical Wnt signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VIM, WRAP53, and PRSS22, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VIM grouped by Positive regulation of canonical Wnt signaling pathway-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	VIM →	-4.052	-0.257	<.001	.002	3	6
LARGE_INTESTINE	WRAP53 →	-0.809	-0.273	<.001	<.001	3	5
LUNG_NSCLC_LUSC	PRSS22 →	+3.081	+0.161	.002	.006	2	6
BLOOD_Myeloma	ARAP2 →	+1.194	+0.110	<.001	.007	3	5
BREAST	KDM4D →	-0.522	-0.205	<.001	<.001	3	5
LUNG_NSCLC_LUAD	C1orf210 →	+2.018	+0.120	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VIM by Positive regulation of canonical Wnt signaling pathway activity — OVARY

Explore this box plot interactively →