Positive regulation of canonical Wnt signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of canonical Wnt signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FEZ2, C2orf15, and TTC9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of canonical Wnt signaling pathway activity versus FEZ2 in LUNG_SCLC (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FEZ2 →	-1.380	-0.196	<.001	<.001	3	7
LUNG_SCLC	C2orf15 →	+2.297	+0.197	<.001	.001	3	7
BLOOD_Leukemia	TTC9 →	+1.285	+0.175	.001	.002	3	6
LUNG_SCLC	FGD3 →	+2.740	+0.172	<.001	.009	3	5
LARGE_INTESTINE	TRAFD1 →	+0.731	+0.127	.001	.002	3	5
LARGE_INTESTINE	YEATS2 →	+0.699	+0.133	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090263 vs FEZ2 — LUNG_SCLC

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