Regulation of retinal ganglion cell axon guidance

Across TCGA patient cohorts, RNA activity of the Regulation of retinal ganglion cell axon guidance pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYTH3, TNFRSF14, and NRP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of retinal ganglion cell axon guidance activity versus CYTH3 in LUAD (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CYTH3 →	+0.767	+0.412	<.001	<.001	3	4
CCRCC	TNFRSF14 →	+0.441	+0.198	.003	.001	3	4
LUAD	NRP1 →	+0.848	+0.492	<.001	<.001	3	4
LSCC	CYB561D2 →	+0.205	+0.409	.006	.007	3	3
LUAD	GBGT1 →	+0.416	+0.288	.002	.006	3	3
LSCC	RGS19 →	+0.318	+0.469	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090259 vs CYTH3 — LUAD

Explore this scatter interactively →