Regulation of spindle organization

Across TCGA cell cohorts, RNA activity of the Regulation of spindle organization pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDSL, C9orf16, and DNAH5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SDSL grouped by Regulation of spindle organization-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SDSL →	+1.386	+0.198	<.001	<.001	3	4
OESOPHAGUS	C9orf16 →	+1.053	+0.178	<.001	.008	3	4
OVARY	DNAH5 →	+0.928	+0.167	.001	.003	3	4
URINARY_TRACT	OBI1 →	-1.067	-0.196	<.001	.008	3	4
UPPER_AERODIGESTIVE_TRACT	RHOF →	+2.840	+0.170	<.001	<.001	3	4
LUNG_NSCLC_LUAD	PRKAR1A →	-0.921	-0.194	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SDSL by Regulation of spindle organization activity — OESOPHAGUS

Explore this box plot interactively →