Negative regulation of cholesterol metabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of cholesterol metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ERLIN2, PLPBP, and ASH2L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cholesterol metabolic process activity versus ERLIN2 in BRCA (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ERLIN2 →	+0.438	+0.064	<.001	<.001	3	5
BRCA	PLPBP →	+0.370	+0.068	<.001	<.001	3	5
OV	ASH2L →	+0.278	+0.084	<.001	.005	3	4
LSCC	SPTBN1 →	+0.138	+0.033	.002	.007	3	4
LSCC	DHPS →	-0.278	-0.045	.006	.003	3	4
HNSC	SON_S2357 →	-0.418	-0.096	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090206 vs ERLIN2 — BRCA

Explore this scatter interactively →