Negative regulation of cholesterol metabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of cholesterol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCAR, BIVM, and LINC02020, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cholesterol metabolic process activity versus FCAR in BRCA (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FCAR →	+0.360	+0.198	<.001	<.001	3	4
CCRCC	BIVM →	+0.583	+0.120	.003	.001	3	3
CCRCC	LINC02020 →	+0.012	+0.098	<.001	.001	3	3
UCEC	POLR1B →	+0.400	+0.179	.002	<.001	3	3
UCEC	IRAK2 →	+0.921	+0.113	<.001	.002	3	3
GBM	CHIAP1 →	-0.189	-0.156	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090206 vs FCAR — BRCA

Explore this scatter interactively →