Negative regulation of cholesterol metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of cholesterol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERLIN2, CADM4, and ERLIN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cholesterol metabolic process activity versus ERLIN2 in BREAST (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ERLIN2 →	+1.659	+1.229	<.001	<.001	3	6
LARGE_INTESTINE	CADM4 →	-2.451	-1.000	<.001	.003	3	5
BLOOD_Leukemia	ERLIN1 →	+1.063	+1.126	.001	<.001	3	5
BLOOD_Leukemia	USP49 →	-1.280	-0.805	<.001	<.001	3	4
LARGE_INTESTINE	PDRG1 →	-1.074	-1.018	<.001	.001	3	4
BLOOD_Leukemia	PAPSS2 →	+1.474	+1.068	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090206 vs ERLIN2 — BREAST

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