Positive regulation of cholesterol metabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of cholesterol metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSU1, UTP15, and HPGDS, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cholesterol metabolic process activity versus RSU1 in BRCA (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RSU1 →	+0.308	+0.057	<.001	<.001	3	7
LUAD	UTP15 →	-0.386	-0.083	<.001	<.001	3	7
LSCC	HPGDS →	+0.479	+0.078	<.001	<.001	3	7
BRCA	ANP32E →	-0.402	-0.043	.001	<.001	3	7
BRCA	MSH6_S227 →	-0.750	-0.051	<.001	<.001	3	7
BRCA	POP1 →	-0.370	-0.062	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090205 vs RSU1 — BRCA

Explore this scatter interactively →