Positive regulation of cholesterol metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of cholesterol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHPRH, UBA2, and RHOT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cholesterol metabolic process activity versus SHPRH in BLOOD_Myeloma (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SHPRH →	+0.802	+0.256	.005	<.001	3	5
BLOOD_Myeloma	UBA2 →	+0.735	+0.258	.002	<.001	3	4
BLOOD_Myeloma	RHOT1 →	+0.770	+0.323	<.001	<.001	3	4
BLOOD_Myeloma	ZNF507 →	+0.598	+0.233	.006	<.001	3	4
BLOOD_Myeloma	KATNA1 →	+0.999	+0.308	<.001	.001	3	4
BLOOD_Myeloma	CLTCL1 →	+1.955	+0.271	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090205 vs SHPRH — BLOOD_Myeloma

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