Positive regulation of release of cytochrome c from mitochondria

Across TCGA patient cohorts, RNA activity of the Positive regulation of release of cytochrome c from mitochondria pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NNMT, ITGB5, and COL1A1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of release of cytochrome c from mitochondria activity versus NNMT in GBM (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NNMT →	+1.239	+0.075	<.001	<.001	3	8
GBM	ITGB5 →	+0.536	+0.082	<.001	<.001	3	7
GBM	COL1A1 →	+0.714	+0.068	<.001	<.001	3	6
COAD	COLEC12 →	+0.675	+0.040	<.001	<.001	3	6
COAD	FAP →	+0.726	+0.033	.002	.001	3	6
BRCA	MRPS21 →	-0.391	-0.043	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090200 vs NNMT — GBM

Explore this scatter interactively →