Positive regulation of release of cytochrome c from mitochondria

Across TCGA cell cohorts, RNA activity of the Positive regulation of release of cytochrome c from mitochondria pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM22, CIAO1, and DDB2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRIM22 grouped by Positive regulation of release of cytochrome c from mitochondria-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TRIM22 →	-2.400	-1.263	.003	<.001	3	6
BREAST	CIAO1 →	+0.527	+1.012	.004	.004	3	5
SOFT_TISSUE	DDB2 →	-1.331	-1.728	<.001	<.001	3	5
SOFT_TISSUE	APOBEC3C →	-2.887	-1.767	<.001	<.001	3	5
SKIN	CDKN1A →	-2.682	-1.099	<.001	.003	3	5
LARGE_INTESTINE	RPS27L →	-1.128	-1.541	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRIM22 by Positive regulation of release of cytochrome c from mitochondria activity — CNS

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