Positive regulation of release of cytochrome c from mitochondria

Across TCGA cell cohorts, RNA activity of the Positive regulation of release of cytochrome c from mitochondria pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFI44, FDXR, and IFIT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of release of cytochrome c from mitochondria activity versus IFI44 in OVARY (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	IFI44 →	-2.901	-0.273	<.001	.001	3	5
OVARY	FDXR →	+1.683	+0.271	.001	.001	3	5
SKIN	IFIT1 →	-2.190	-0.315	<.001	<.001	3	5
OVARY	REXO2 →	-1.021	-0.327	<.001	.007	3	4
STOMACH	SLC37A2 →	-1.611	-0.228	.005	.002	3	4
OESOPHAGUS	HPDL →	+1.740	+0.144	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090200 vs IFI44 — OVARY

Explore this scatter interactively →