Regulation of release of cytochrome c from mitochondria

Across TCGA patient cohorts, RNA activity of the Regulation of release of cytochrome c from mitochondria pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FN1, AMPD3, and IL4I1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of release of cytochrome c from mitochondria activity versus FN1 in GBM (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FN1 →	+0.548	+0.050	<.001	<.001	3	6
GBM	AMPD3 →	+0.672	+0.066	<.001	<.001	3	6
GBM	IL4I1 →	+0.817	+0.069	<.001	<.001	3	6
CCRCC	CTHRC1 →	+0.698	+0.034	<.001	<.001	3	6
GBM	FAP →	+0.803	+0.069	<.001	<.001	3	6
CCRCC	PLAU →	+0.825	+0.064	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090199 vs FN1 — GBM

Explore this scatter interactively →