Regulation of release of cytochrome c from mitochondria

Across TCGA patient cohorts, RNA activity of the Regulation of release of cytochrome c from mitochondria pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCN1, TGFB1I1, and MMP14, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of release of cytochrome c from mitochondria activity versus CCN1 in BRCA (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CCN1 →	+0.930	+0.219	<.001	<.001	3	5
BRCA	TGFB1I1 →	+0.694	+0.181	<.001	<.001	3	5
BRCA	MMP14 →	+1.185	+0.293	<.001	<.001	3	5
BRCA	LMNA →	+0.552	+0.180	.002	.005	3	5
BRCA	BGN →	+1.430	+0.341	<.001	<.001	3	5
PDAC	CDH13 →	+0.538	+0.194	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090199 vs CCN1 — BRCA

Explore this scatter interactively →