Regulation of release of cytochrome c from mitochondria

Across TCGA cell cohorts, RNA activity of the Regulation of release of cytochrome c from mitochondria pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IQGAP3, SLC30A7, and YME1L1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of release of cytochrome c from mitochondria activity versus IQGAP3 in SOFT_TISSUE (Pearson r = -0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IQGAP3 →	-1.206	-0.266	<.001	<.001	3	5
LIVER	SLC30A7 →	-0.566	-0.276	.009	.005	3	5
KIDNEY	YME1L1 →	-0.775	-0.288	.006	.003	3	5
LUNG_NSCLC_LUSC	NTPCR →	-0.984	-0.272	.002	.004	3	4
KIDNEY	CENPL →	-1.552	-0.329	.004	.003	3	4
KIDNEY	KIFC1 →	-1.061	-0.220	.006	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090199 vs IQGAP3 — SOFT_TISSUE

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