Positive regulation of glomerulus development

Across TCGA patient cohorts, RNA activity of the Positive regulation of glomerulus development pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are A2M, SERPIND1, and SMTN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of glomerulus development activity versus A2M in UCEC (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A2M →	-0.416	-0.162	.005	<.001	3	5
LUAD	SERPIND1 →	-0.261	-0.088	.007	.006	3	5
COAD	SMTN →	-0.703	-0.144	<.001	<.001	3	5
COAD	TNS1 →	-0.380	-0.101	<.001	<.001	3	5
CCRCC	CAVIN1 →	-0.468	-0.154	<.001	<.001	3	5
COAD	CAVIN3 →	-0.518	-0.137	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090193 vs A2M — UCEC

Explore this scatter interactively →