Positive regulation of glomerulus development

Across TCGA cell cohorts, RNA activity of the Positive regulation of glomerulus development pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BMERB1, AP1B1, and MGLL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BMERB1 grouped by Positive regulation of glomerulus development-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	BMERB1 →	+3.560	+1.583	<.001	.008	3	6
BLOOD_Lymphoma	AP1B1 →	-0.805	-1.643	.001	.003	3	4
LUNG_NSCLC_LUSC	MGLL →	-3.040	-1.209	.005	.003	3	4
KIDNEY	PHF23 →	-0.633	-1.113	.005	.008	3	4
LARGE_INTESTINE	CARD8 →	+0.912	+1.273	.006	<.001	3	4
OESOPHAGUS	SLC25A11 →	-0.618	-0.954	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BMERB1 by Positive regulation of glomerulus development activity — URINARY_TRACT

Explore this box plot interactively →