Positive regulation of glomerulus development

Across TCGA cell cohorts, RNA activity of the Positive regulation of glomerulus development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP3CA, CERS4, and CYS1, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of glomerulus development activity versus PPP3CA in SOFT_TISSUE (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PPP3CA →	+2.759	+1.430	<.001	<.001	3	17
STOMACH	CERS4 →	-2.552	-0.956	<.001	.001	3	7
LUNG_NSCLC_LUAD	CYS1 →	-0.475	-0.423	.001	.001	3	7
LUNG_SCLC	ABCG4 →	-0.553	-0.663	.001	<.001	3	7
OESOPHAGUS	KIF26A →	-1.908	-0.784	<.001	.007	3	7
OVARY	RADIL →	-1.017	-0.984	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090193 vs PPP3CA — SOFT_TISSUE

Explore this scatter interactively →