Regulation of glomerulus development

Across TCGA patient cohorts, RNA activity of the Regulation of glomerulus development pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GIMAP8, LAMC3, and MYBBP1A_S11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glomerulus development activity versus GIMAP8 in PDAC (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	GIMAP8 →	-0.279	-0.120	<.001	<.001	3	4
PDAC	LAMC3 →	-0.445	-0.137	.005	<.001	3	4
PDAC	MYBBP1A_S11 →	-0.316	-0.103	.002	.003	3	4
GBM	METAP1 →	+0.176	+0.079	.002	.003	3	4
UCEC	AMOT →	+0.449	+0.143	<.001	.007	3	4
CCRCC	SPG7 →	-0.227	-0.085	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090192 vs GIMAP8 — PDAC

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