Regulation of glomerulus development

Across TCGA patient cohorts, RNA activity of the Regulation of glomerulus development pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIGZ, SNAP25, and CHDH, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glomerulus development activity versus PIGZ in GBM (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PIGZ →	+0.350	+0.541	.001	.002	3	3
GBM	SNAP25 →	+1.250	+0.702	<.001	<.001	3	3
HNSC	CHDH →	+0.843	+0.623	.001	.003	3	3
HNSC	CTTNBP2 →	+0.729	+0.580	.003	.005	3	3
GBM	KCNA2 →	+1.021	+0.659	.002	.005	3	3
GBM	KRT8P51 →	+0.407	+0.612	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090192 vs PIGZ — GBM

Explore this scatter interactively →