Regulation of glomerulus development

Across TCGA cell cohorts, RNA activity of the Regulation of glomerulus development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LPAR6, AP1B1, and C18orf21, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LPAR6 grouped by Regulation of glomerulus development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LPAR6 →	-1.402	-0.991	<.001	<.001	3	4
BLOOD_Lymphoma	AP1B1 →	-0.814	-1.586	<.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	C18orf21 →	+1.153	+1.478	.003	<.001	3	4
LUNG_NSCLC_LUAD	CHMP2B →	-0.673	-0.766	<.001	<.001	3	4
LARGE_INTESTINE	SLC25A38 →	+0.681	+0.903	<.001	.001	3	4
LARGE_INTESTINE	PSIP1 →	+0.908	+0.958	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LPAR6 by Regulation of glomerulus development activity — BREAST

Explore this box plot interactively →