Regulation of glomerulus development

Across TCGA cell cohorts, RNA activity of the Regulation of glomerulus development pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACADL, LYPLA1, and ABHD14A-ACY1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACADL grouped by Regulation of glomerulus development-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ACADL →	-0.258	-1.006	.001	.001	3	4
BONE	LYPLA1 →	-0.197	-0.414	.009	.007	3	4
KIDNEY	ABHD14A-ACY1 →	-0.212	-1.149	.001	.002	3	4
URINARY_TRACT	HIPK3 →	-0.304	-1.822	.004	<.001	3	3
LIVER	ZFPM2 →	-0.194	-1.968	.005	<.001	3	3
BLOOD_Lymphoma	PDE6D →	+0.281	+1.830	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACADL by Regulation of glomerulus development activity — OVARY

Explore this box plot interactively →