Regulation of branching involved in ureteric bud morphogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of branching involved in ureteric bud morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP6R1, AKNA_S1387, and EHBP1L1_S1257, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of branching involved in ureteric bud morphogenesis activity versus PPP6R1 in GBM (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PPP6R1 →	-0.264	-0.147	<.001	<.001	3	6
GBM	AKNA_S1387 →	-0.790	-0.227	.001	.001	3	6
HNSC	EHBP1L1_S1257 →	-0.351	-0.086	<.001	<.001	3	6
GBM	RASAL3_S228 →	-0.564	-0.098	.002	.008	3	5
GBM	RGS19_S65 →	-0.818	-0.134	<.001	.001	3	5
GBM	SERPINB1 →	-0.728	-0.162	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090189 vs PPP6R1 — GBM

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