Regulation of branching involved in ureteric bud morphogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of branching involved in ureteric bud morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDFY1, ANKRD10, and ZNF227, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WDFY1 grouped by Regulation of branching involved in ureteric bud morphogenesis-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	WDFY1 →	-0.996	-1.086	.003	.001	3	4
PANCREAS	ANKRD10 →	-1.075	-0.681	.001	.009	3	4
SKIN	ZNF227 →	+0.464	+0.663	<.001	.007	3	4
SKIN	PMEL →	-5.119	-1.144	.003	.001	3	4
LUNG_NSCLC_LUAD	CDC16 →	-0.760	-0.567	<.001	<.001	3	3
PANCREAS	ABHD13 →	-0.901	-1.342	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WDFY1 by Regulation of branching involved in ureteric bud morphogenesis activity — SKIN

Explore this box plot interactively →