Regulation of branching involved in ureteric bud morphogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of branching involved in ureteric bud morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF223, LIX1L, and MSRB3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of branching involved in ureteric bud morphogenesis activity versus RNF223 in STOMACH (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RNF223 →	+1.892	+1.837	.005	.006	3	8
OESOPHAGUS	LIX1L →	-3.154	-1.792	<.001	<.001	3	8
BREAST	MSRB3 →	-2.709	-1.600	<.001	<.001	3	7
OVARY	TACSTD2 →	+5.777	+1.337	<.001	<.001	3	6
LUNG_NSCLC_LUAD	TMEM105 →	+1.488	+1.752	.004	<.001	3	6
OVARY	TMEM265 →	+2.868	+1.361	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090189 vs RNF223 — STOMACH

Explore this scatter interactively →