Regulation of kidney development

Across TCGA cell cohorts, RNA activity of the Regulation of kidney development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BASP1, TGFBI, and LRRK1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of kidney development activity versus BASP1 in SOFT_TISSUE (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	BASP1 →	+6.135	+2.025	<.001	<.001	3	8
SOFT_TISSUE	TGFBI →	+6.337	+1.942	.003	<.001	3	6
SOFT_TISSUE	LRRK1 →	+3.215	+1.694	<.001	<.001	3	5
SOFT_TISSUE	NABP1 →	+3.712	+2.006	.005	<.001	3	5
SOFT_TISSUE	GSDMD →	+4.657	+1.887	<.001	<.001	3	5
OVARY	EHD2 →	+3.050	+1.200	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090183 vs BASP1 — SOFT_TISSUE

Explore this scatter interactively →