Organelle membrane fusion

Across TCGA patient cohorts, RNA activity of the Organelle membrane fusion pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTF3C4, UTP25, and CASP8AP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organelle membrane fusion activity versus GTF3C4 in LSCC (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GTF3C4 →	-0.527	-0.167	.002	.002	3	6
LSCC	UTP25 →	-0.426	-0.139	.002	.001	3	5
CCRCC	CASP8AP2 →	-0.217	-0.139	.004	<.001	3	5
LUAD	ZNF669 →	-0.313	-0.120	.005	.007	3	5
LSCC	SMC3 →	-0.440	-0.139	<.001	.001	3	4
LSCC	ACVR2B →	-0.688	-0.152	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090174 vs GTF3C4 — LSCC

Explore this scatter interactively →