Organelle membrane fusion

Across TCGA cell cohorts, RNA activity of the Organelle membrane fusion pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASAH1, TMEM87B, and BTK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organelle membrane fusion activity versus ASAH1 in SKIN (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ASAH1 →	+2.053	+0.210	<.001	<.001	3	5
LIVER	TMEM87B →	+0.954	+0.240	.002	.004	3	4
SKIN	BTK →	+0.909	+0.202	<.001	<.001	3	3
OVARY	CTNNA1 →	+0.676	+0.147	.005	.003	3	3
SKIN	TBC1D7 →	+2.454	+0.254	<.001	<.001	3	3
BONE	FLVCR1 →	-0.767	-0.251	.001	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090174 vs ASAH1 — SKIN

Explore this scatter interactively →