Regulation of spindle assembly

Across TCGA patient cohorts, RNA activity of the Regulation of spindle assembly pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TPX2, RFC2, and RPL12_S38, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of spindle assembly activity versus TPX2 in BRCA (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TPX2 →	+0.925	+0.055	<.001	<.001	3	10
UCEC	RFC2 →	+0.378	+0.074	<.001	<.001	3	9
OV	RPL12_S38 →	+1.029	+0.062	.003	<.001	3	9
BRCA	TPX2_S738 →	+1.084	+0.044	<.001	<.001	3	9
BRCA	MKI67 →	+0.810	+0.045	<.001	<.001	3	9
GBM	KIF11_T926 →	+1.291	+0.070	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090169 vs TPX2 — BRCA

Explore this scatter interactively →