Regulation of spindle assembly

Across TCGA patient cohorts, RNA activity of the Regulation of spindle assembly pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCKAP5-IT1, BNIP3L, and ARMCX5-GPRASP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of spindle assembly activity versus NCKAP5-IT1 in PDAC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	NCKAP5-IT1 →	+0.531	+0.176	<.001	<.001	3	5
LSCC	BNIP3L →	+0.433	+0.137	.002	<.001	3	4
LSCC	ARMCX5-GPRASP2 →	+0.389	+0.154	.005	<.001	3	4
PDAC	EEA1 →	+0.270	+0.112	.006	.005	3	4
PDAC	RNGTT →	+0.210	+0.111	<.001	<.001	3	4
PDAC	CTTNBP2NL →	+0.280	+0.115	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090169 vs NCKAP5-IT1 — PDAC

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