Regulation of spindle assembly

Across TCGA cell cohorts, RNA activity of the Regulation of spindle assembly pathway is significantly associated with the protein abundance of multiple proteins, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CHMP1B, CHMP1A, and CHMP2B, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of spindle assembly activity versus CHMP1B in SKIN (Pearson r = 0.72).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CHMP1B →	+0.957	+0.210	<.001	<.001	3	11
LARGE_INTESTINE	CHMP1A →	+0.905	+0.187	<.001	.001	3	10
URINARY_TRACT	CHMP2B →	+1.735	+0.228	.005	.004	3	9
URINARY_TRACT	IST1 →	+1.085	+0.258	<.001	<.001	3	9
LARGE_INTESTINE	CD2AP →	+1.451	+0.233	<.001	<.001	3	9
LARGE_INTESTINE	WASF2 →	+0.750	+0.161	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090169 vs CHMP1B — SKIN

Explore this scatter interactively →