Golgi disassembly

Across TCGA patient cohorts, RNA activity of the Golgi disassembly pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLAU, P3H1, and PPP1R18_S224, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi disassembly activity versus PLAU in LUAD (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PLAU →	+0.820	+0.077	.001	<.001	3	7
BRCA	P3H1 →	+0.509	+0.055	.001	<.001	3	6
BRCA	PPP1R18_S224 →	+0.583	+0.059	<.001	<.001	3	6
CCRCC	C1QC →	+0.484	+0.038	<.001	.001	3	6
LSCC	UNC13D →	+0.594	+0.094	<.001	<.001	3	6
LUAD	NRBF2 →	+0.163	+0.069	.006	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090166 vs PLAU — LUAD

Explore this scatter interactively →