Golgi disassembly

Across TCGA patient cohorts, RNA activity of the Golgi disassembly pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP26, SNCA, and SHCBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi disassembly activity versus DUSP26 in GBM (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DUSP26 →	-1.077	-0.134	.003	.002	3	5
PDAC	SNCA →	-0.416	-0.152	<.001	<.001	3	5
LUAD	SHCBP1 →	+0.555	+0.194	<.001	<.001	3	5
LUAD	SPAG5 →	+0.958	+0.297	<.001	<.001	3	4
UCEC	TSPAN7 →	-0.921	-0.170	.006	.002	3	4
LUAD	MGP →	-0.825	-0.196	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090166 vs DUSP26 — GBM

Explore this scatter interactively →