Golgi disassembly

Across TCGA cell cohorts, RNA activity of the Golgi disassembly pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FADS3, MAPK8, and VDAC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FADS3 grouped by Golgi disassembly-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FADS3 →	-0.816	-0.217	.005	<.001	3	4
BREAST	MAPK8 →	-0.726	-0.174	.007	<.001	3	4
LUNG_NSCLC_LUSC	VDAC2 →	-0.683	-0.185	.001	.005	3	4
BLOOD_Leukemia	ZFYVE27 →	-0.560	-0.239	.005	.004	2	5
BLOOD_Leukemia	CWF19L1 →	-0.733	-0.266	<.001	<.001	3	4
OESOPHAGUS	HHIPL2 →	+1.502	+0.240	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FADS3 by Golgi disassembly activity — LARGE_INTESTINE

Explore this box plot interactively →