Golgi disassembly

Across TCGA cell cohorts, RNA activity of the Golgi disassembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUP188, HELLS, and FANCM, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi disassembly activity versus NUP188 in BLOOD_Lymphoma (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NUP188 →	+0.581	+0.762	.001	<.001	3	6
LARGE_INTESTINE	HELLS →	+1.010	+0.477	.001	.007	3	6
LUNG_SCLC	FANCM →	+0.710	+0.195	<.001	.002	3	6
LUNG_SCLC	PPP4R3A →	+0.858	+0.241	.003	<.001	3	5
BLOOD_Leukemia	DNA2 →	+0.759	+0.376	.001	.007	2	6
LARGE_INTESTINE	CDK1 →	+0.695	+0.348	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090166 vs NUP188 — BLOOD_Lymphoma

Explore this scatter interactively →