Golgi ribbon formation

Across TCGA patient cohorts, RNA activity of the Golgi ribbon formation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF395, SPIDR, and MIR4420, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi ribbon formation activity versus ZNF395 in HNSC (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZNF395 →	-0.674	-0.259	.001	.002	3	5
HNSC	SPIDR →	-0.383	-0.186	.002	.001	3	4
LUAD	MIR4420 →	+0.752	+0.131	.005	.006	3	3
HNSC	MIR4797 →	-0.999	-0.235	.004	.009	3	3
BRCA	ZNF268 →	-0.368	-0.414	<.001	.002	3	3
LSCC	TRIT1 →	-0.403	-0.214	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090161 vs ZNF395 — HNSC

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